The chromatographic technique which utilizes nonpolar adsorbent surface and a polar eluent historically has been named "Reversed-Phase HPLC". Since 1974 when reversed-phase packing materials became commercially available, RP-HPLC quickly grown in its number of applications, and now it is the most widely used HPLC mode.
This success could be explained by its ability to separate a large variety of organic compounds and related components especially .
Reversed-phase separation of the reaction mixture for synthesis of high-temperature
polymers. More than sixty components has been detected.