The definition of detector response depends on whether it is mass-sensitive or concentration-sensitive. For mass-sensitive detectors, the response R (mV/mass/unit time) is given by the following relationship:

For the concentration sensitive detector, sensitivity is given in units of mV/mass/unit volume and it can be calculated using the following formula:

The symbols have the following meaning:
h = peak height (mV)
w = peak width at 0.607 of the peak height (cm)
F = flow rate (ml/min)
M = mass of solute injected
s = chart speed (cm/min)

In addition to factors such as the nature of the mobile phase, cell geometry, and so on, the detector response is also a function of the type of solute.